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Biological Role of Inorganic Pyrophosphate

<p>Dr. Heinonen reviews and critically evaluates the scientific  literature on the biological role of inorganic pyrophosphate (PPi )  published from 1940 to the end of 1999. He describes and classifies  all known biochemical reactions that produce Ppi; describes and  evaluates all published methods used in biological Ppi; and compiles  and critically evaluates information on the concentration of PPi (with  the conclusion that, contrary to common belief, PPi exists throughout  the living world in rather high concentrations). Many reactions in  which PPi is used as a biochemical energy source instead of ATP have  been described in recent decades, especially in bacteria, protists,  and plants. These reactions are evaluated from the bioenergetic and  regulatory points of view. Also considered is the possible role of PPi  as a source of biochemical energy in the primitive phases of life,  before ATP. Data is presented on the regulatory role of PPi in living  systems, such as activities of enzymes, fidelity of syntheses of  macromolecules, and proliferation of cells. PPi may also regulate the  formation and dissolution of bone as well as pathologic calcification  of soft tissues and the formation of urinary stones. The formation of  calcium pyrophosphate dihydrate crystals in the extracellular fluids  of joints cause the disease called pseudogout. <br></br>  Biological Role of Inorganic Pyrophosphate book is a unique and  invaluable source of references (about 1120) and summarized data for  professionals who study or plan to study the role of PPi in living  systems. Many different branches of science (biochemistry,  microbiology, bioenergetics, plant physiology, parasitology,  evolution, orthopedics, rheumatology) have involvement with PPi. This  book sums up available knowledge in one place and will help scientists  cross disciplinary boundaries.</p>

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Biological Role of Inorganic Pyrophosphate

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