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Chitosan : A natural solubility enhancer for simvastatin

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<p>The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) to produce cost effective formulation.Physical mixture, co-grinding method, spray drying method are compared.Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.</p><br/><p>BIO-DATA                                                         Name: Pattewar Seema Venkatrao (Patil)& Deepak patilQualification: M.Pharm Experience: academic field.Presently working in Sanjivani institute of pharmacy and research,Kopargaon,INDIA</p>

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