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Introduction to Population Pharmacokinetic/Pharmacodynamic Analysis with Nonlinear Mixed Effects Models

<p><b>A Guide to the Most Powerful Tool for Population Pharmacokinetic / Pharmacodynamic Analysis</b></p> <p>Population pharmacokinetic / pharmacodynamic analysis using Nonlinear Mixed Effects Modeling (NONMEM) is an approach that has gained substantial importance in pharmacometrics. NONMEM is the primary tool employed and is the keystone in novel initiatives on quantitative model-based drug development led by the US FDA, professional organizations, and the pharmaceutical industry</p> <p>This book uses a hands-on approach to introduce all aspects of NONMEM, how to use the system, and the concepts behind specific methods. As a didactic tool, it gives the reader an overview and provides critical information, including: </p> <ul> <li>Fundamentals: Population model concepts and terminology</li> <li>Requisite concepts for using NONMEM: writing control streams, model building, and evaluation aspects</li> <li>Examples of nonlinear modeling concepts and estimation basics with discussion on Bay

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